Neuroprotective Effect of Genistein Studies in Rat Models of Parkinson’s and Alzheimer’s Disease
نویسنده
چکیده
8 SAMMANFATTNING 9 ABBREVIATIONS 10 INTRODUCTION 11 Parkinson’s disease 11 Hallmarks of Parkinson’s disease 11 Risk factors 11 Genetic 12 Non-genetic 12 Evaluation of drugs 14 Animal models of Parkinson’s disease 16 Alzheimer’s disease 18 Hallmarks of Alzheimer’s disease 18 Amyloid beta 19 Pathology 21 Astrogliosis in Alzheimer’s disease 22 Risk factors 22 Genetic 23 Non-genetic 25 Evaluation of drugs 26 Animal models of Alzheimer’s disease 28 Phytoestrogens 31 Genistein metabolism 31 Pharmacological properties of genistein 32 Effect of phytoestrogens/genistein 32 AIMS OF THE RESEARCH 34 METHODOLGY 35 Genestein treatment 35 Surgery 35 Behavioral tests 36 Biochemistry 37 Perfusion, nissl staining 38 Immunohistochemistry 39 Cell counting 39 Morphometric study of astrocytes 39 RESULTS & DISCUSSIONS 41 Effects of genistein in a 6-OHDA rat model of Parkinson disease 41 Effects of genistein on learning & memory deficit in an Aβ1-40 rat model of AD 42
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تاریخ انتشار 2012